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Ebola

Ebola virus disease is a viral but often fatal hemorrhagic fever. Since its discovery in 1976, it has affected several countries in Central, West and East Africa, with major outbreaks, particularly in Guinea between 2013 and 2016

ALIMA (The Alliance for International Medical Action) plays a key role in the fight against Ebola. In addition to treating patients, the NGO innovates in treatments, prevention, and vaccination to curb the spread of the virus and save lives. 

What is Ebola virus disease?

Ebola virus disease (EVD) is an acute viral infection with an average fatality rate of 50% (ranging from 30% to 90% depending on the strain) (WHO). The virus belongs to the filovirus family and is transmitted through direct contact with the body fluids of an infected person or animal. 

 

Origin and transmission of the Ebola virus

Where does the Ebola virus come from?

Named after a river in the Democratic Republic of Congo (DRC), where the first outbreaks occurred in 1976, Ebola has since triggered over 20 epidemics across Central and West Africa.

 

How is Ebola transmitted?

  • Animal transmission: fruit bats are suspected of being the natural reservoir of the virus. Contact with infected animals (monkeys, antelopes, porcupines) can lead to human infection.
  • Human-to-human transmission: the virus spreads via direct contact with an infected person’s body fluids (blood, sweat, urine, saliva, etc.). It can also be transmitted through unprotected sex or from mother to child through breastfeeding.
  • Exposure of healthcare staff: without adequate protection, healthcare workers are particularly at risk. 

 

Essential prevention measures 

  • Frequent handwashing
  • Use of personal protective equipment (masks, gloves)
  • Rapid isolation of infected patients
  • Community awareness campaigns
  • Vaccination 

 

What are the symptoms of the Ebola virus? 

Symptoms appear between 2 and 21 days after infection. 

 

Early symptoms:

  • High fever (+38°C)
  • Extreme fatigue
  • Headache and sore throat

 

Advanced symptoms:

  • Vomiting and diarrhea
  • Rashes
  • Internal and external bleeding 

 

Early diagnosis and rapid medical intervention significantly increase the chances of survival. 

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Ebola treatments and vaccines

Recommended treatments 

Since 2022, the WHO recommends two monoclonal antibody treatments proven to be effective against the Zaire strain of Ebola:

 

When administered early, these treatments increase the chances of recovery.

 

Vaccines against Ebola Zaire

  • rVSV-ZEBOV: demonstrated 100% efficacy in a 2015 trial in Guinea.
  • Ad26.ZEBOV and MVA-BN-Filo (Janssen): WHO-validated to strengthen protection.

 

Ongoing studies, such as PREVAC, led by ALIMA and its partners, continue to optimize vaccine strategies.

ALIMA's commitment in the fight against Ebola

Actions on the ground

Since 2014, ALIMA has been actively involved in the outbreaks in the DRC and Guinea: 

 

A major innovation: the CUBE 

ALIMA has developed the Biosecure Emergency Room for Epidemics (CUBE), a care unit to isolate and treat patients while limiting risks for caregivers. 

In 2019, Bill Gates awarded ALIMA the Game-Changing Innovator” prize at the Reaching the Last Mile Forum in Abu Dhabi.

 

ALIMA, a key player in Ebola research 

In collaboration with INSERM, the WHO, and other partners, ALIMA participates in several research programs aimed at: 

  • Improving treatments
  • Optimizing vaccination strategies
  • Reduce mortality rates

 

The PALM study, to which ALIMA contributed in the DRC, demonstrated that early treatment can lower mortality rates to below 10%.

On the ground

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